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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 October;163(5):139-44


language: English

Ca 125 blood levels and heart failure: a strong relationship

Varvarigos N. 1, Kappas A. 1, Avramopoulou T. H. 1, Kalogeropoulou K. 2, Papaioannou H. A. 1, Dimakopoulos N. 2, Migdalis I. N. 3, Galanis C. 1, Mortzos G. 2

1 Department of Cardiology, NIMTS Hospital, Athens, Greece; 2 Department of Nuclear, NIMTS Hospital, Athens, Greece; 3 Second Department of Internal Medicine, NIMTS Hospital, Athens, Greece


Aim. CA 125, a wide­ly ­used tu­mor mark­er for ovar­ian can­cer was re­port­ed to be al­so el­e­vat­ed in ­some be­nign con­di­tions. Recently, it has ­been ob­served to be a suc­cess­ful prog­nos­tic fac­tor in ­heart fail­ure pa­tients pre and post­heart trans­plan­ta­tion. Aim of ­this ­study was to ­find if ­there is a re­la­tion­ship ­between CA 125 ­blood lev­els and ­heart func­tion­al stat­us.
Methods. CA 125 ­blood lev­els ­were de­ter­mined in 72 pa­tients (49 men and 23 wom­en, ­aged 72,4±10.85 ­years) ­with ­heart fail­ure. CA 125 nor­mal val­ues ­were 0-35 U/ml. The re­sults ­were ­grouped ac­cord­ing to the clin­i­cal stat­us (New York Heart Association Classificatio, NY­HA) and the ejec­tion frac­tion of the pa­tients, as was de­ter­mined by ­both ra­dio­nu­clide ven­tric­u­log­ra­phy and car­diac ultra­sound, and an­a­lyzed by Pearson Correlation ­test, ANO­VA and χ2 ­test of ­SPSS 8.0 sta­tis­ti­cal pro­gram. The fe­male pa­tients ­with el­e­vat­ed CA 125 lev­els ­were ex­am­ined for ovar­ian can­cer.
Results. CA 125 lev­els ac­cord­ing to NY­HA ­were the fol­low­ing: ­stage 1: 6.4±5.8 (14 pa­tients), ­stage 2: 37.4±32.69 (22 pa­tients), ­stage 3: 108.2±40.27 (21 pa­tients) and ­stage 4: 303.9± 270.9 (15 pa­tients). There ­were 23 fe­male pa­tients ­with el­e­vat­ed CA 125 ­blood lev­els ­which under­went ultra­so­nog­ra­phy or CT-­scan and in all 23 pa­tients ovar­ian can­cer was ex­clud­ed. Statistical anal­y­sis re­vealed a sig­nif­i­cant re­la­tion­ship ­between CA 125 and NY­HA ­stage (p: 0.012). Significant neg­a­tive cor­re­la­tion was al­so ­found ­between CA 125 and ra­dio­nu­clide ejec­tion frac­tion, ­with p-val­ue: 0.002 and Pearson cor­re­la­tion co­ef­fi­cient: -0.642 as ­well as ­between CA 125 and ­echo ejec­tion frac­tion ­with p-val­ue: 0.004 and Pearson cor­re­la­tion co­ef­fi­cient: -0.582 and frac­tion­al short­en­ing (p-val­ue: 0.006 and Pearson cor­re­la­tion co­ef­fi­cient: -0.525).
Conclusion. CA 125, ­besides an ex­cel­lent ovar­ian can­cer mark­er, is al­so a mark­er of ­heart func­tion­al stat­us. The de­ter­mi­na­tion of CA 125 ­blood lev­els may be a use­ful ­tool in ­heart fail­ure man­age­ment.

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