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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2004 August;163(4):121-5

Copyright © 2004 EDIZIONI MINERVA MEDICA

language: Italian

Male breast cancer: report of two cases

Panier Suffat P., Bianco A., Calello G., Guffanti P., Monticone C., Ramellini G., Tozzi D., Tridico F., Truda G., Panier Suffat L.

Sezione di Chirurgia Generale e Oncologica, Dipartimento di Discipline Medico-Chirurgiche, Università degli Studi di Torino, Torino


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­Male ­breast ­cancer is a ­rare neo­plasm ­with an inci­dence of ­about 1% of all ­breast ­cancer in ­both gen­ders. ­Many fac­tors are ­involved in the path­o­gen­esis ­such as gynec­o­mastia, hered­i­tary and ­genetic fac­tors, ­estrogen admin­is­tra­tion and dis­eases asso­ciated ­with hyper­es­tro­genism.
Two ­cases of ­male ­breast ­cancer are ­reported and the etio­logic and prog­nostic fac­tors, the diag­nostic ­work-up and sur­gical and com­ple­men­tary ­therapy are exam­ined. ­Male ­breast ­cancer, com­pared ­with the ­female one, is char­ac­ter­ized by a ­higher hor­mone recep­tors pos­i­tivity. The neo­plasm ­site, ­more fre­quently ­located in the sub­are­olar ­region, may ­delay diag­nosis and treat­ment. The treat­ment of ­choice is ­total mas­tec­tomy ­with axil­lary lym­phoa­de­nec­tomy ­according to ­Patey or to ­Halsted. Adju­vant chem­o­therapy and radio­therapy are ­often asso­ciated. The prog­nosis in ­both gen­ders is ­about the ­same for ­each ­stage but, for the rel­a­tively low inci­dence of the ­pathology in men, diag­nosis is ­made in a ­more ­advanced ­stage ­with a ­worse prog­nosis.

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