ORIGINAL ARTICLES   

Gazzetta Medica Italiana Archivio per le Scienze Mediche 2001 April;160(2):45-7

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: English

Heredity of the haemostatic disorders in non insulin dependent diabetes (NIDDM)

Trifiletti A., Lasco A., Scamardi R., Pizzoleo M. A., Sottilotta G., Gaudio A., Larocca R., Reitano N., Barbera N.

Department of Internal Medicine, University of Messina

Background. Changes of plasma levels of different haemostatic variables have been described in patients with non insulin dependent diabetes (NIDDM). These changes can be important in cardiovascular events occurring frequently in diabetic patients and, may be, in healthy children of type 2 diabetics too. The aim of this study is the evaluation of plasma levels of various haemostatic markers in two groups of subjects, with and without diabetic familiarity.
Methods. In 40 non-diabetic first-degree relatives of type 2 diabetic patients and in 46 controls, with no family history of diabetes, plasma levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-I), D-dimer (DD) and prothrombin fragment 1+2 (F1+2) were evaluated.
Results. In relatives we detected higher t-PA and PAI-1 plasma levels than the controls (p<0.002). As far as DD and F1+2 are concerned we did not detect any significant difference between relatives and controls.
Conclusions. Our data could indicate a possible family history of haemostatic disorders in NIDDM.