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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2000 August;159(4):125-7

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

Hemostatic disorders in different stages of peripheral vascular disease

Trifiletti A., Scamardi R., Pizzoleo M. A., Attinà A., Sottilotta G., Barbera N.

Department of Internal Medicine, University of Messina


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Background. Hemostatic dis­or­ders oc­cur in the clin­i­cal his­to­ry of pe­riph­er­al oc­clu­sive ar­te­ri­al dis­ease (­POAD). The ­aims of ­this ­study ­were to con­firm ­these he­mo­stat­ic chang­es and to iden­ti­fy wheth­er par­tic­u­lar stag­es of ­POAD ­were ­more like­ly to ­show ­these dis­or­ders ­than oth­ers.
Methods. In 68 non-di­a­bet­ic pa­tients ­with oblit­er­a­tive ar­ter­i­op­a­thies of the low­er ­limbs, in 41 age-ma­tched vol­un­teers and in 14 pa­tients ­with ­acute pneu­mo­nia, throm­bo­mod­u­lin (TM), be­ta-throm­bo­glob­u­lin (β-TG), D-dim­er (DD), plas­mi­no­gen ac­ti­va­tor-in­hib­i­tor (PAI-1), pro­throm­bin frag­ment 1+2 (F1+2) and fi­brin­o­pep­tide A (FPA) ­were eval­u­at­ed.
Results. The ob­served val­ues ­show a sig­nif­i­cant in­crease, in ­stage II pa­tients, of TM, β-TG and DD plas­ma lev­els. The ­stage III pa­tients al­so ­show PAI-1 and F1+2 high­er ­than the con­trols. All the pa­ram­e­ters ­were ­found to be sig­nif­i­cant­ly high­er in ­stage IV pa­tients.
Conclusions. These ­data con­firm ­that in vas­cu­lo­path­ic pa­tients, en­do­the­li­um dam­age, plate­let ac­ti­va­tion, im­paired fi­brin­o­lyt­ic po­ten­tial and in­crease of fi­brin ­turn-­over grad­u­al­ly oc­cur and may ­play an im­por­tant ­role in the de­vel­op­ment of the throm­bot­ic le­sions.

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