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Minerva Gastroenterology 2022 Jan 10

DOI: 10.23736/S2724-5985.21.02926-0


language: English

Probiotics in the treatment of Helicobacter pylori infection: reality and perspective

Guzel ISAEVA 1, 2 , Regina ISAEVA 3

1 Kazan Research Institute of Epidemiology and Microbiology, Kazan, Russian Federation; 2 Microbiology Department, Kazan State Medical University, Kazan, Russian Federation; 3 I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation


Helicobacter pylori (H. pylori) infection is one of the most common in the world today, associated with the development of acute or chronic inflammatory diseases of the gastroduodenal tract. In order to eradicate the pathogen, various antibacterial therapy regimens have been proposed, based on the use of several chemotherapeutic drugs and a proton pump inhibitor (PPI). However, recent studies indicate a decrease in antibiotic effectiveness due to both the growth rate of H. pylori resistance and side effects, often due to the development of dysbiosis. One of the promising areas of investigation is the treatment with probiotic therapy of helicobacteriosis. The use of probiotics, in the context of H. pylori infection, has two main reasons. The first is related to the use of certain probiotics to reduce the frequency of undesirable gastrointestinal consequences during H. pylori eradication therapy. The second is associated with the antagonistic effect of individual probiotics on H. pylori and the potentiation of the eradication effect. The purpose of this review was to summarize the latest data on the use of probiotics to enhance H. pylori eradication and to restore the gastrointestinal microbiota. Many unresolved questions, about the choice of the specific composition of the probiotic cocktail, dosage, duration of therapy, mechanisms of the antimicrobial action of probiotics, as well as possible negative consequences of such therapy, remain.

KEY WORDS: Helicobacter pylori; Microbiota; Probiotics; Antibiotics

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