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Minerva Gastroenterology 2021 Dec 21

DOI: 10.23736/S2724-5985.21.02982-X


language: English

Evaluation of MACK-3 parameters, metabolic and fibrotic characteristics of non-alcoholic fatty liver disease patients with hypertension

Oleg BABAK 1, Kateryna LAPSHYNA 1 , Konstantyn PROSOLENKO 1, Arkadiy CHERNYAK 2, Olena GOPTSIY 1

1 Kharkiv National Medical University, Kharkiv, Ukraine; 2 Government Institution L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine (GI L.T.Mala NIT NAMSU), Kharkiv, Ukraine


BACKGROUND: Non-alcoholic steatohepatitis (NASH) is an inflammatory subtype of non-alcoholic fatty liver disease (NAFLD) and recent non-invasive test, MACK-3, demonstrated good diagnostic characteristics for fibrosis in a number of studies. The aim of our study was to assess the liver state using the non-invasive MACK-3 test, and its link with liver fibrosis stage, inflammatory activity, steatosis and metabolic markers in NAFLD patients with hypertension (HT).
METHODS: Thirty adult NAFLD patients with HT, aged 30 to 60 years (mean age (46.36 ± 5.1) years) were included in our study. The control group consisted of 20 healthy volunteers. In addition to basic laboratory tests and ultrasonographic examination, validated non-invasive fibrosis test were performed. MACK-3 was calculated using the online calculator with the following variables: fasting glucose, fasting insulin, aspartate aminotransferase (AST) and cytokeratin 18 (CK18).
RESULTS: All NAFLD patients with HT were characterized with increased liver enzymatic activity, lipid profile, increased levels of insulin and HOMAIR (˂ 0.001). MACK-3 parameters were positively correlated with thymol test - direct link - r = 0.45 (p <0.013), with aspartataminotransferase (AST) r = 0.38 (p <0.03) and alanineaminotransferase (ALT) - r = 0.38 (p<0.03), with the stage of Fibrotest activity r = 0.25 (p <0.018) and steatosis r = 0.76 (p <0.001).
CONCLUSIONS: MACK-3 parameters associations with hepatic enzymatic activity, steatosis and activity stage suggest this test as a promising for screening use in such patients and requires further studies.

KEY WORDS: Non-alcoholic fatty liver disease (NAFLD); Non-alcoholic steatohepatitis (NASH); fibrosis; MACK-3

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