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Minerva Gastroenterology 2021 Jul 19

DOI: 10.23736/S2724-5985.21.02888-6

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Histology of ibd and related colitides in the elderly

Giuseppe LEONCINI 1 , Luca REGGIANI-BONETTI 2, Gloria SIMONCELLI 3, Vincenzo VILLANACCI 3

1 Pathology Unit, ASST del Garda, Desenzano del Garda, Brescia, Italy; 2 Pathology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 3 Institute of Pathology Spedali Civili, Brescia Italy


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Inflammatory bowel disease (IBD) are chronic relapsing diseases, affecting both children and adults with a life-long duration. An increased co-morbidity gives raise to fragility in the elderly. In this regard it should take into account that several non-IBD colitides may mimic both ulcerative colitis and Crohn's disease. Moreover, chronic diseases represent a clinical challenge, mostly about treatment effectiveness.
Finally, it is worth noting that patients with long-standing diseases - and elderly patients among them - have an increased malignancy risk when compared to general (non-IBD) population. Our paper aims to review the three main histological topics that play a role in the clinical management of IBD in the elderly, namely differential diagnosis, mucosal healing and IBD-associated dysplasia.


KEY WORDS: IBD, Ulcerative colitis; Crohn’s disease; Non-IBD colitis; Dysplasia

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