Home > Journals > Minerva Gastroenterology > Past Issues > Articles online first > Minerva Gastroenterology 2021 May 10

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

 

Minerva Gastroenterology 2021 May 10

DOI: 10.23736/S2724-5985.21.02852-7

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet is associated with increased risk of uninvestigated chronic dyspepsia and its symptoms in adults

Payman ADIBI 1, Ahmad ESMAILLZADEH 2, Hamed DAGHAGHZADEH 1, Ammar HASSANZADEH KESHTELI 3, Awat FEIZI 4, Fahimeh HAGHIGHATDOOST 5, Mohammad JAFARI 1

1 Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; 2 Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; 3 Department of Medicine, University of Alberta, Edmonton, AB, Canada; 4 Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran; 5 Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran


PDF


BACKGROUND: Assessing the potential effects of a low- fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet on functional gastrointestinal symptoms, particularly upper gastrointestinal symptoms, is not clearly understood. The current study aimed at exploring the association of a diet low in FODMAPs with uninvestigated chronic dyspepsia (UCD) and functional dyspeptic symptoms in a large population of Iranian adults.
METHODS: This cross-sectional study was conducted on 2987 adults. Dietary FODMAPs intake estimated using a validated food-frequency questionnaire. UCD, early satiation, postprandial fullness and gastric pain were determined using a modified and validated version of the Rome III questionnaire.
RESULTS: After controlling for various confounders, consumption of a diet low in FODMAPs was associated with increased risk of UCD in the whole population (OR=1.85; 95% CI: 1.23, 2.78; P=0.009) and women (OR=2.41; 95% CI: 1.46, 3.95; P=0.004), but not in men. Higher consumption of a low-FODMAPs diet was related to increased risk of postprandial fullness (OR=1.38; 95% CI: 1.08, 1.78; P=0.046). The inverse association between FODMAPs and epigastric pain tended to be significant after controlling for eating behaviors (OR=1.31; 95% CI: 0.98, 1.76; P=0.084). No significant association was observed for early satiation.
CONCLUSIONS: Our data suggest that consumption of a low-FODMAPs diet may increase the risk of UCD and postprandial fullness; however, well-planned randomized controlled trials and prospective cohorts are required to ascertain the effect of FODMAPs on upper gastrointestinal symptoms.


KEY WORDS: FODMAPs; Diet; Functional gastrointestinal disorders; Dyspepsia; Postprandial fullness

top of page