ORIGINAL ARTICLE   Free access

Minerva Gastroenterology 2022 March;68(1):77-84

DOI: 10.23736/S2724-5985.20.02664-1

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Efficacy of artichoke and ginger extracts with simethicone to treat gastrointestinal symptoms in endurance athletes: a pilot study

Franchek DROBNIC ^{1, 2} ✉, Sergi FONTS ³, Iker GARCÍA-ALDAY ¹, Giovanna PETRANGOLINI ⁴, Antonella RIVA ⁴, Elisabetta FRATTINI ⁴, Pietro ALLEGRINI ⁴, Stefano TOGNI ⁴, Jacopo VITALE ⁵

¹ Department of Sport Sciences Research, Sant Cugat del Vallés Olympic Training Center, Barcelona, Spain; ² Barcelona FC Medical Services, Sant Joan Despí, Barcelona, Spain; ³ Kronos Sport Nutritional Assessment, Rubí, Barcelona, Spain; ⁴ Indena S.p.A., Milan, Italy; ⁵ IRCCS Galeazzi Orthopedic Institute, Milan, Italy

BACKGROUND: Exercise-induced gastrointestinal (GI) symptoms are frequently reported by athletes during training and competitions. A standardized combination of artichoke leaves and ginger root extracts has shown beneficial effects in managing GI discomfort in otherwise healthy subjects.
METHODS: In this pilot study, we assessed the effectiveness of artichoke leaves and ginger root extracts combination associated with simethicone in reducing exercise-related GI symptoms in endurance athletes. The effects of the combination on upper/lower GI and systemic symptoms were assessed at baseline and after 4 weeks through a questionnaire.
RESULTS: Fifty endurance athletes took the extracts’ combination 320 mg + simethicone 40 mg chewable pills. The extracts combination and simethicone were effective in reducing the mean intensity of upper GI (86.6%) lower GI (85.9%) and systemic symptoms (81.9%), with superior results compared to placebo. The most remarkable effects were reported in the lower GI tract, with a significant decrease in flatulence, intestinal cramps, loose stools and diarrhea. Athletes also benefited from a reduction in belching and bloating and in dizziness, headache and muscle cramps, although the decrease in systemic symptoms was not significant.
CONCLUSIONS: The supplementation of standardized artichoke and ginger extracts, combined with simethicone, may be effective in decreasing digestive discomfort and alteration of gastric motility not only in healthy subjects but also in endurance athletes.

KEY WORDS: Digestive signs and symptoms; Ginger; Cynara; Athletes; Nausea