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Minerva Gastroenterologica e Dietologica 2020 September;66(3):211-8

DOI: 10.23736/S1121-421X.20.02669-0


language: English

Effects of Hoodia Parviflora on satiety, abdominal obesity and weight in a group of overweight subjects: a randomized, blinded, placebo-controlled trial

Simone PERNA 1, Vittoria INFANTINO 2, Gabriella PERONI 3 , Clara GASPARRI 3, Milena A. FALIVA 3, Maurizio NASO 3, Tariq A. ALALWAN 1, Filippo BORSANI 4, Martina BERARDI 4, Zahra ILYAS 1, Zahraa ALAALI 1, Layla ALSOWAID 1, Daniele SPADACCINI 3, Mariangela RONDANELLI 2, 5

1 Department of Biology, College of Science, University of Bahrain, Sakhir, Bahrain; 2 Unit of Human and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy; 3 Unit of Endocrinology and Nutrition, Azienda di Servizi alla Persona Istituto Santa Margherita, University of Pavia, Pavia, Italy; 4 PromoPharma S.p.A. Acquaviva, San Marino, Italy; 5 IRCCS Mondino Foundation, Pavia, Italy

BACKGROUND: This study aimed to assess the effects of supplementation with Hoodia Parviflora (H. Parviflora) at 9 mg+200 mg of fructo-oligosaccharides on weight loss, body composition, hydration and satiety parameters.
METHODS: A randomized blinded controlled trial was conducted in a sample of 30 overweight and obese patients (5 males and 25 females). Patients were randomly assigned in 2 groups: the intervention group, which received H. Parviflora twice a day for 4 weeks and the control group, which received a placebo.
RESULTS: After a 4-week follow-up period, the study results showed an improvement of Δ=-1.632 kg (Confidence Interval [CI]95% -2.545; -0.719) and a statistically significant decrease in waist circumference (WC) compared with the placebo group -2.080 cm ([CI]95% -4.082; -0.078). The visual analogue scale reported an improvement of satiety sensation after day 5 (P=0.001).
CONCLUSIONS: This study shows for the first time the simultaneous effect of H. Parviflora on weight loss, decreasing satiety, and improving fat mass, in particular Visceral Adipose Tissue (VAT).

KEY WORDS: Hoodia; Obesity; Satiety response; Intra-abdominal fat

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