REVIEW   

Minerva Gastroenterologica e Dietologica 2018 December;64(4):363-75

DOI: 10.23736/S1121-421X.18.02507-2

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Post-pancreatitis diabetes mellitus: towards understanding the role of gastrointestinal motility

Fuchsia D. GOLD-SMITH, Shayal K. CHAND, Maxim S. PETROV ✉

Department of Surgery, University of Auckland, Auckland, New Zealand

Post-pancreatitis diabetes mellitus (PPDM) is a sub-type of diabetes of the exocrine pancreas that develops after acute or chronic inflammation of the pancreas. While pro-inflammatory milieu, glucose metabolism, and lipid metabolism in PPDM have been investigated, little is known about gastrointestinal function in the post-pancreatitis setting. This article overviews studies on epidemiology and impact of gastroparesis in the setting of type 1 and type 2 diabetes, with a view to estimating the possible burden of gastrointestinal dysfunction in PPDM. Further, the usefulness of quantifying gastrointestinal dysmotility is discussed. The gastroparesis cardinal symptom index has emerged as a standardized gastrointestinal dysmotility endpoint and its use in individuals after pancreatitis is justified.

KEY WORDS: Pancreatitis - Type 2 diabetes mellitus - Gastrointestinal diseases - Gastroparesis