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Minerva Gastroenterologica e Dietologica 2010 June;56(2):213-31

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

An approach to the management of re-fractory ulcerative colitis

Sonu I. 1, Blonski W. 2, 3, Lin M. V. 4, Lichtenstein G. R. 2

1 University of Pennsylvania, School of Medicine, Philadelphia, PA, USA; 2 Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA; 3 Department of Gastroenterology, Medical University, Wroclaw, Poland; 4 Department of Internal Medicine, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA


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Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology associated with dysregulation of the gastrointestinal mucosal immune system. It is characterized by a waxing and waning course and approximately 15% of UC patients will experience a severe episode. The first line treatment for severe colitis includes IV corticosteroids, however, 40% of patients are non-responsive to corticosteroid therapy and may require either colectomy, intravenous infliximab or intravenous cyclosporine within 3-5 days of presentation. This review focuses on the management and treatment approaches to refractory UC.

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