![]() |
JOURNAL TOOLS |
Publishing options |
eTOC |
To subscribe |
Submit an article |
Recommend to your librarian |
ARTICLE TOOLS |
Reprints |
Permissions |
Share |


YOUR ACCOUNT
YOUR ORDERS
SHOPPING BASKET
Items: 0
Total amount: € 0,00
HOW TO ORDER
YOUR SUBSCRIPTIONS
YOUR ARTICLES
YOUR EBOOKS
COUPON
ACCESSIBILITY
ORIGINAL ARTICLES
Minerva Gastroenterologica e Dietologica 2010 March;56(1):13-17
Copyright © 2010 EDIZIONI MINERVA MEDICA
language: English
Accuracy of serum pepsinogens I and II, gastrin-17 and anti-helicobacter pylori antibodies in histological diagnoses of atrophic gastritis
Irvani S. 1, Hashemi M. R. 1, Moghadam K. G. 2, Saeidee S. 1, Khavaran K. 1, Najari O. 3, Ranavardi M. 3, Nasiri S. 3, Salmasian H. 4, Rohanizadegan M. 4 ✉
1 Department of Gastroenterology, Army University of Medical Sciences, Tehran, Iran; 2 Department of Pathology, Army University of Medical Sciences, Tehran, Iran; 3 Army University of Medical Sciences, Tehran, Iran; 4 Tehran University of Medical Sciences, Tehran, Iran
AIM: Atrophic gastritis is defined as a chronic inflammatory process in gastric mucosa leading to loss of glandular cells. It is considered a precancerous condition, thus its early diagnosis is of importance. Although histo-pathologic studies remain as the gold standard of diagnosis, non-invasive methods suitable for screening purposes are being developed. This includes measurement of serum gastric profile.
METHODS: Two hundred and fifty 250 patients who were planned to undergo upper gastrointestinal endoscopy were randomly selected to be included in this study. Serum levels of pepsinogen I and II, gastrin-17 and anti-Helicobacter pylori (Hp) antibody were measured and the results were compared with that of histopathologic assessment of biopsy specimens obtained during endoscopy.
RESULTS: IgG anti-Hp, PGII and PGI/PGII ratio showed correlation with age. PGI/PGII ratio showed best sensitivity (96.1%) and negative predictive value (97.7%). PGI has the highest specificity (94.6%), and PGII also had a high negative predictive value (90.7%). IgG anti-Hp showed poor sensitivity and specificity (58.8% and 26.5%, respectively).
CONCLUSIONS: Pepsinogen I/II ratio appears to be the most suitable single measurement for screening purposes in atrophic gastritis.