Home > Journals > Minerva Gastroenterology > Past Issues > Minerva Gastroenterologica e Dietologica 1999 March;45(1) > Minerva Gastroenterologica e Dietologica 1999 March;45(1):43-50

CURRENT ISSUE
 

JOURNAL TOOLS

Publishing options
eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions
Share

 

REVIEWS   

Minerva Gastroenterologica e Dietologica 1999 March;45(1):43-50

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: English

Gastroesophageal reflux disease. Pathogenesis, symptoms and complications

Cioffi U., Rosso L., De Simone M.


Full text temporarily not available online. Contact us


The onset of GERD depends on several factors leading to a prolonged exposition of the esophageal mucosa to inflammatory agents. Various mechanisms play a role in different patients, but generally, decreased LES tone and delayed esophageal clearance are the major causes. Although pyrosis and regurgitation are the most frequent complaints, the patient may have different symptoms or can be asymptomatic. The symptoms are not necessarily correlated with damaged mucosa. Recognized complications caused by reflux include esophagitis, stricture, hemorrhage, Barrett¹s epithelium and ulceration, aspiration and respiratory implications. The severity of complications may be an important element in predicting whether the patient can be successfully treated medically or surgically. The exact knowledge of the pathogenesis is mandatory for carrying out the most effective treatment.

top of page