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Minerva Gastroenterologica e Dietologica 2020 Dec 03

DOI: 10.23736/S1121-421X.20.02798-1

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Eosinophilic esophagitis: definition, epidemiology and quality of life

Leonardo FRAZZONI 1 , Salvatore TOLONE 2

1 Department of Medical and Surgical Sciences, Gastroenterology Unit, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 2 Department of Surgery, Mini-Invasive and Bariatric Surgery Unit, University of Campania, Napoli, Italy


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Eosinophilic esophagitis (EoE) is a clinicopathological disease defined by symptoms of esophageal dysfunction and ≥15 eosinophils/HPF after excluding other causes of esophageal eosinophilia. Increasing attention has been paid by clinicians and researchers after its first description in 1978. Many consensuses and guidelines have been issued over the years, as gastroenterologists did not reach an agreement on EoE definition, especially regarding the controversial responsiveness to proton pump inhibitor (PPI) therapy. Of note, recent evidence suggests that the incidence and prevalence of EoE have been increasing through the years: many risk factors have been advocated as possible reasons for this, although further studies are needed. In this brief review, we will first cover the history of EoE in the literature, with a focus on its varying definition throughout the years. Then, we will discuss EoE epidemiology, emphasizing potential risk factors explaining its increasing incidence and prevalence. Last, we will deal with the quality of life of adult and pediatric patients with EoE.


KEY WORDS: Eosinophilic esophagitis; Definite disease; Dysphagia

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