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MINERVA GASTROENTEROLOGICA E DIETOLOGICA

A Journal on Gastroenterology, Nutrition and Dietetics


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Minerva Gastroenterologica e Dietologica 2018 Mar 30

DOI: 10.23736/S1121-421X.18.02493-5

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Role of microbiota in the autism spectrum disorders

Daniela CAMPION, Paola PONZO , Carlo ALESSANDRIA, Giorgio M. SARACCO, Federico BALZOLA

Division of Gastroenterology, Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy


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Autism Spectrum Disorder (ASD) defines a set of neurodevelopmental disorders characterized by persistent deficits in social communication and interaction, along with repetitive patterns of behavior. Symptoms generally appear in the early developmental period and cause significant impairment in individual and social functioning. In recent years the increased prevalence of ASD, along with the evidence of a significant link between autism and gastrointestinal (GI) disturbances, raised a special interest in exploringì the reciprocal influences between gut and brain. Investigators highlighted the existence of a so-called “gut-brain axis”, empowering the hypothesis that GI abnormalities could trigger neuropsychiatric symptoms in ASD. Intestinal microbiota is thought to play a pivotal role in gut and systemic homeostasis, in CNS development, as well as in behavioral modulation and recurrent microbial imbalances have been shown in gut microbiota of autistic people. In this review we analyze current knowledge about intestinal microbiota and the relevance and role of dysbiosis in ASD. The most accredited theories about gut-brain interaction will be reviewed, along with current scientific evidence supporting the relationship between microbial imbalances and impairment of neurodevelopment. Finally, we will focus on the results of different therapeutic approaches in this context: administration of pre- and probiotics, antibiotics, fecal microbiota transplantation and special diets and dietary supplements.


KEY WORDS: Autism spectrum disorder - Microbiota - Dysbiosis - Probiotics - Fecal microbiota transplantation

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Publication History

Article first published online: March 30, 2018
Manuscript accepted: March 23, 2018
Manuscript received: March 22, 2018

Cite this article as

Campion D, Ponzo P, Alessandria C, Saracco GM, Balzola F. Role of microbiota in the autism spectrum disorders. Minerva Gastroenterol Dietol 2018 Mar 30. DOI: 10.23736/S1121-421X.18.02493-5

Corresponding author e-mail

paola.ponzo2@gmail.com