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A Journal on Gastroenterology, Nutrition and Dietetics

Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index



Minerva Gastroenterologica e Dietologica 2018 Mar 30

DOI: 10.23736/S1121-421X.18.02490-X


language: English

Helicobacter pylori in metabolic related diseases

Gianenrico RIZZATTI , Maria V. MATTEO, Gianluca IANIRO, Giovanni CAMMAROTA, Francesco FRANCESCHI, Antonio GASBARRINI

Internal Medicine, Gastroenterology and Liver Disease Unit, Gastroenterological Area, Gastroenterological-Endocrinometabolic Sciences Department, Fondazione Policlinico A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy


Helicobacter pylori is one of the most common gastrointestinal infection affecting humans worldwide. Hp colonizes the stomach with preferential trophism for the antrum. Hp infection is associated with the development of a chronic gastritis and subsequently with several gastric diseases such as peptic disease, gastric carcinoma and MALT lymphoma. Moreover, Helicobacter pylori infection has also been reported in literature to be associated with many other extra-gastric conditions including sideropenic anemia, thrombocytopenia, neurological, liver and cardiovascular diseases. For some conditions the association is supported by solid literature data and also by the identification of the possible physiopathogenetic mechanism involved. In other cases the link is only reported by association studies often with conflicting results. In this context, diabetes mellitus, cardiovascular disorders and liver steatosis have all been reported to be associated with Helicobacter pylori infection. Interestingly, these conditions share many characteristics and they often overlap as they represent the expression of the so called metabolic syndrome. Aim of the review is to summarize the available data regarding the association between Helicobacter Pylori infection and diabetes mellitus, cardiovascular disorders and liver steatosis.

KEY WORDS: Helicobacter pylori - Metabolic syndrome - Diabetes mellitus - Cardiovascular Disease - Non-alcoholic fatty liver disease

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Publication History

Article first published online: March 30, 2018
Manuscript accepted: March 16, 2018
Manuscript received: March 12, 2018

Cite this article as

Rizzatti G, Matteo MV, Ianiro G, Cammarota G, Franceschi F, Gasbarrini A. Helicobacter pylori in metabolic related diseases. Minerva Gastroenterol Dietol 2018 Mar 30. DOI: 10.23736/S1121-421X.18.02490-X

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