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MINERVA GASTROENTEROLOGICA E DIETOLOGICA

A Journal on Gastroenterology, Nutrition and Dietetics


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Minerva Gastroenterologica e Dietologica 2017 Oct 09

DOI: 10.23736/S1121-421X.17.02329-7

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Sorbitol malabsorption in patients with abdominal discomfort

Birgit KLEE 1, Oliver BARSKE 1, Andrea MACK 1, Christoph K. THOERINGER 1, Bernhard HALLER 2, Valentin BECKER 1 , Simon NENNSTIEL 1

1 Medizinische Klinik und Poliklinik, Klinikum Rechts der Isar der Technischen Universität München, München, Germany; 2 Institut für Medizinische Statistik und Epidemiologie, Klinikum Rechts der Isar der Technischen Universität München, München, Germany


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BACKGROUND: The role of sorbitol malabsorption in patients with functional abdominal discomfort has not been finally clarified yet. Therefore, aim of this study was to evaluate the clinical significance of sorbitol malabsorption, diagnosed by sorbitol hydrogen breath testing in these patients.
METHODS: Data of all patients referred to our hospital for hydrogen breath testing between May, 1st 2013 and December 31st, 2014 were retrospectively collected and analyzed. Patients with confirmed sorbitol malabsorption completed a symptombased questionnaire before and after nutritional counseling.
RESULTS: 510 patients with functional abdominal discomfort (65.5 % female, 34.5% male; mean age 45 years (± 16.4 years) were referred to our hospital for hydrogen breath testing. H2-Sorbitol-breath tests were done in 252 of these patients. In 122 patients (48%) sorbitol-malabsorption was diagnosed. In 66 of these patients (54%) the symptom-based questionnaire showed a significant improvement of the frequency of abdominal discomfort (p<0.001) and of the influence of these symptoms on daily life (p<0.001) in patients after nutritional counseling/dietary adjustment.
CONCLUSIONS: Sorbitol-malabsorption is a common finding in patients with functional abdominal discomfort. Dietary intervention positively affects abdominal symptoms in these patients.


KEY WORDS: Carbohydrate malabsorption - Sorbitol - Hydrogen breath testing - Abdominal discomfort - Nutritional counseling

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Publication History

Article first published online: October 9, 2017
Manuscript accepted: October 6, 2017
Manuscript revised: September 18, 2017
Manuscript received: August 23, 2016

Cite this article as

Klee B, Barske O, Mack A, Thoeringer CK, Haller B, Becker V, et al. Sorbitol malabsorption in patients with abdominal discomfort. Minerva Gastroenterol Dietol 2017 Oct 09. DOI: 10.23736/S1121-421X.17.02329-7

Corresponding author e-mail

becker@gastroenterologie-isartor.de