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PANCREATIC DISEASES: A CLOSER LOOK
Minerva Gastroenterologica e Dietologica 2012 December;58(4):331-45
Copyright © 2012 EDIZIONI MINERVA MEDICA
language: English
Diabetes and pancreatic cancer
Muniraj T. 1, Chari S. T. 2 ✉
1 Yale University School of Medicine, New Haven, CT USA; 2 Mayo Clinic College of Medicine, Rochester MN USA
The relationship between diabetes and pancreatic cancer is complex. Diabetes or impaired glucose tolerance is present in more than 2/3rd of pancreatic cancer patients. Epidemiological studies have consistently shown a modest increase in the risk of pancreatic cancer in type 2 diabetes, with an inverse relationship to duration of disease. Additionally, recent studies suggest that anti-diabetic medications may modulate the risk of pancreatic cancer in type 2 diabetes. Subjects >50 years of age with new onset diabetes are at higher risk of having pancreatic cancer. However, to screen new-onset diabetes for pancreatic cancer, additional markers are needed that can distinguish pancreatic cancer-associated diabetes from type 2 diabetes.