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Minerva Gastroenterologica e Dietologica 2001 September;47(3):129-36

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: English

Helicobacter pylori: a culprit in extraintestinal diseases?

Cremonini F., Canducci F., Gabrielli M., Di Caro S., Santarelli L., Nista E. C., Lupascu A., Gasbarrini G., Gasbarrini A.


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Known risk factors for many diseases considered ''multifactorial'' or ''idiopathic'' do not overlap with disease prevalence. These conditions include cardiovascular and cerebrovascular diseases, functional vascular diseases and several immunomediated disorders. Much evidence has linked the state of chronic inflammation, present in such conditions, to Helicobacter pylori chronic infection. Many molecular mechanisms have been hypothesized to explain its action. Epidemiological studies do not exclude a correlation between the infection and cardiovascular and cerebrovascular diseases but are flawed by confusing factors which make it difficult to draw conclusions. Moreover, various therapeutic studies have attempted to show if antibiotic treatment improves prognosis in patients affected by several skin diseases and hematologic conditions such as iron-deficiency anemia and autoimmune thrombocytopenia. Still, none of these trials has completely cleared the effects of H. pylori eradication on the clinical progression of such disorders.

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