Home > Journals > European Journal of Physical and Rehabilitation Medicine > Past Issues > European Journal of Physical and Rehabilitation Medicine 2020 April;56(2) > European Journal of Physical and Rehabilitation Medicine 2020 April;56(2):184-90

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as

 

ORIGINAL ARTICLE   Freefree

European Journal of Physical and Rehabilitation Medicine 2020 April;56(2):184-90

DOI: 10.23736/S1973-9087.20.05991-2

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Sarcopenia, osteoporosis and the burden of prevalent vertebral fractures: a cross-sectional study of 350 women with hip fracture

Marco DI MONACO 1 , Carlotta CASTIGLIONI 1, Francesca BARDESONO 2, Edoardo MILANO 1, Giuseppe MASSAZZA 2

1 Osteoporosis Research Center, Division of Physical and Rehabilitation Medicine, Presidio Sanitario San Camillo, Opera San Camillo Foundation, Turin, Italy; 2 Division of Physical and Rehabilitation Medicine, Department of Surgical Sciences, University of Turin, Turin, Italy



BACKGROUND: The concurrent presence of sarcopenia and osteoporosis may enhance fracture risk.
AIM: The aim of this study was to evaluate the association between sarcopenia, osteoporosis, or the concurrent presence of both the conditions (osteosarcopenia) and the burden (number and severity) of vertebral fractures in women with hip fracture.
DESIGN: Cross-sectional study.
SETTING: Division of Physical and Rehabilitation Medicine.
POPULATION: We studied 350 women with subacute hip fracture.
METHODS: Lateral radiographs of the spine were taken 18.2±4.5 days after fracture occurrence and the Spine Deformity Index (SDI) was calculated. Body composition was assessed by dual-energy X-ray absorptiometry. Low muscle mass was identified with appendicular lean mass <15.02 kg and low bone mineral density with a femoral T-Score <-2.5.
RESULTS: The presence of sarcopenia (P=0.033) and osteoporosis (P=0.032) was associated with the SDI scores independently of each other and independently of age, percentage of body fat and hip-fracture type. The 350 women were categorized into 3 groups according to the absence of both osteoporosis and sarcopenia (N.=25), presence of either osteoporosis or sarcopenia (N.=95) or presence of osteosarcopenia (N.=230). We found a significant difference in SDI scores across the 3 groups: χ2 (2, N.=350) = 15.29; P<0.001. The categorization of the 350 women into the 3 groups was associated with the SDI scores (P=0.001) independently of age, percentage of body fat and hip-fracture type.
CONCLUSIONS: Both osteoporosis and sarcopenia were independently associated with the burden of prevalent vertebral fractures in women with hip fracture. The concurrent presence of sarcopenia and osteoporosis was associated with a higher SDI Score than the presence of only one of the 2 conditions.
CLINICAL REHABILITATION IMPACT: Subjects with both low bone mass and low muscle mass should be considered at particularly high risk for vertebral fractures. Interventions targeting both the components of the muscle-bone unit, including exercise, nutrition, and possibly new medications, should be investigated to optimize fracture prevention.


KEY WORDS: Body composition; Hip fractures; Osteoporosis; Sarcopenia; Spine

top of page