ORIGINAL ARTICLE   Free access

European Journal of Physical and Rehabilitation Medicine 2020 February;56(1):73-81

DOI: 10.23736/S1973-9087.19.05781-2

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

Preoperative respiratory muscle endurance training improves ventilatory capacity and prevents pulmonary postoperative complications after lung surgery

Hélène LAURENT ^{1, 2, 3} ✉, Sylvie AUBRETON ³, Géraud GALVAING ⁴, Bruno PEREIRA ⁵, Patrick MERLE ⁶, Ruddy RICHARD ^{1, 2, 7}, Frédéric COSTES ^{1, 2, 7}, Marc FILAIRE ^{1, 2, 4}

¹ Clermont Auvergne University, Clermont-Ferrand, France; ² Unit of Human Nutrition, Research Nutrition Center, Clermont-Ferrand, France; ³ Department of Physical Medicine and Rehabilitation, CHU Clermont-Ferrand, Clermont-Ferrand, France; ⁴ Department of Thoracic and Endocrinological Surgery, Center Jean Perrin, Clermont-Ferrand, France; ⁵ CHU Clermont-Ferrand, Délégation à la Recherche Clinique et à l’Innovation (DRCI), Clermont-Ferrand, France; ⁶ Department of Pneumology, CHU Clermont-Ferrand, Clermont-Ferrand, France; ⁷ Department of Sports Medicine and Functional Explorations, CHU Clermont-Ferrand, Clermont-Ferrand, France

BACKGROUND: Resection surgery is the main treatment for non-small cell lung cancer (NSCLC). Postoperative complications and mortality are mostly linked to respiratory failure consecutive to respiratory muscle overload.
AIM: We aimed to evaluate the effect of preoperative respiratory muscle endurance training (RMET) on respiratory muscle capacity and postoperative complications in patients undergoing NSCLC resection.
DESIGN: Randomized controlled trial.
SETTING: French university hospital.
POPULATION: Patients eligible for NSCLC resection.
METHODS: The training group (T group) performed a 3-week preoperative RMET added to usual chest physical therapy while the control group (C group) had only the latter. The primary outcome was the change in respiratory muscle endurance. Secondary outcomes were postoperative complications and mortality. Assessments were performed similarly at baseline and after the intervention. We conducted multivariable analyses with analysis of covariance (ANCOVA) taking into account baseline values for isocapnic hyperpnoea endurance test, exercise capacity and pulmonary function tests. The number of pulmonary postoperative complication was analyzed by Fisher-exact test.
RESULTS: We included 26 patients with NSCLC (14 in the T group and 12 in the C group). Respiratory muscle endurance significantly increased in the T group after the RMET compared with C group (+229±199 vs. -5±371 sec, P=0.001). This increase was associated with a significantly lower number of pulmonary postoperative complications (2 vs. 10, P=0.037).
CONCLUSIONS: Preoperative RMET improved respiratory muscle endurance and decreased pulmonary postoperative complications after surgery for NSCLC. These positive results obtained after RMET may help improve the perioperative course for such patients. These results should be confirmed in larger randomized controlled trials, including higher number of patients especially with altered respiratory muscle function.
CLINICAL REHABILITATION IMPACT: Low-cost and easy to perform, RMET training could serve as complementary tool to usual chest physical therapy, before lung resection surgery.

KEY WORDS: Work of breathing; Lung neoplasms; Muscle fatigue; Respiratory insufficiency