CASE REPORT   

Esperienze Dermatologiche 2021 September;23(3):61-3

DOI: 10.23736/S1128-9155.21.00524-0

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

The Hailey-Hailey disease treated with medical therapy and recently developed advanced dressings

Alessandra SCARABELLO, Mauro BERTA ✉, Carola PULVIRENTI

Department of Dermatology, Spallanzani Hospital, Rome, Italy

We observed three cases, one man and two women, with chronic familial benign pemphigus or Hailey-Hailey disease with the presence of erythematous areas and various district erosions: groin, armpits, inframammary sulcus. In two cases, a man, and a woman, with St. Aureus superinfection. The treatment assigned was based on systemic cortisone (prednisone 25 mg), antioxidants (lactoferrin or polydatin), PEG gel (polyoxyethylene glycol + allantoin) and in cases of systemic antibiotic superinfection (azithromycin and in the other case Clarithromycin). A new type of advanced dressing was recommended at home (3 × patients): gauzes with a porous membrane of polycaprolactone with maltodextrin, collagen, chitosan, and colloidal silver. In the third week of treatment in two cases there was a marked decrease in erythematous areas and erosions in the absence of symptoms (itching, burning, pain and bad odor). In the other case, the objective result showed a less decisive but clear improvement. Therefore, these dressings in combination with traditional therapy protocols could be extended to a greater number of cases for better evaluation.

KEY WORDS: Pemphigus, benign familial; Polycaprolactone; Dermatology