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Esperienze Dermatologiche 2020 December;22(4):53-5

DOI: 10.23736/S1128-9155.21.00511-2

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Positive effect of hybrid stable cooperative complexes of high- and low-molecular-weight hyaluronic acid in psoriasis: a clinical series

Gabriel SIQUIER-DAMETO ^{1, 2} ✉, Laura SOLALINDE ³

¹ Dameto Clinics International, Badhoevedorp, The Netherlands; ² Department of Medical Sciences, Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Universitat de Girona (UdG), Girona, Spain; ³ Dermoestética del Centro Médico La Costa, Asunción, Paraguay

Psoriasis is a chronic, relapsing, inflammatory disease that involves the skin, nails and joints, and is accompanied by a significant impact on patients’ overall quality of life. Topical treatments are frequently prescribed but are not often very successful. Consequently, there is a need for an improvement in psoriasis therapeutic options. In the present work, the therapeutic effect of an injectable hybrid stable cooperative complex (HCC) treatment was evaluated in six adult patients who were affected by psoriasis. HCC treatment was performed twice with 4 weeks between treatments, by intra- and peri-lesional deep-dermal bolus injection. The treatment shows a positive local effect on psoriasis plaques starting from the first injection. An improvement has been observed in both the Psoriasis Area and Severity Index evaluation and photographic evidence. In addition, the pruritus is importantly decreased. Obtained results suggest that HCC injection could be considered as an alternative therapeutic approach in the management of psoriasis.

KEY WORDS: Hyaluronic acid; Psoriasis; Injections