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Esperienze Dermatologiche 2020 September;22(2-3):28-30

DOI: 10.23736/S1128-9155.20.00499-9

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Propylene glycol: the best solvent for minoxidil?

Alfredo ROSSI , Marta MUSCIANESE, Alessandro FEDERICO, Francesca MAGRI, Gemma CARO, Maria C. FORTUNA

Division of Dermatology, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Umberto I Polyclinic Hospital, Sapienza University, Rome, Italy


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Topical minoxidil is nowadays the first line therapy for androgenetic alopecia. A large number of organic compounds are available in order to ensure minoxidil’s stabilization and solubilization, but the solubilization power of each cosolvent is different. The most common solvent used for minoxidil topical preparations is Propylene glycol (PG), which belongs to glycols, a large class of alcohol family. In the Authors’ experience PG is the best solvent for minoxidil topical formulations, but other solvents are more commonly used in galenic formulations in order to reduce the amount of skin adverse effects; on the other hand their expiration date is shorter due to a lower stability of minoxidil. Thanks to the availability of low-concentrated PG products that correlate to a better tolerability and to a lower incidence of allergic and irritative contact dermatitis, in our opinion these, at the moment, represent the best choice.


KEY WORDS: Propylene glycols; Minoxidil; Alopecia

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