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ORIGINAL ARTICLE Free access
Esperienze Dermatologiche 2019 March;21(1):16-21
DOI: 10.23736/S1128-9155.19.00483-7
Copyright © 2019 EDIZIONI MINERVA MEDICA
language: English
Antioxidant action and microflora modulation of Vitachelox® in subjects with acne-prone skin
Giada MARAMALDI 1, Ambra CORTI 2, Stefano TOGNI 1, Martino MENEGHIN 1, Vincenzo NOBILE 3, Luca GIACOMELLI 2, 4 ✉, Jung KATINKA 5
1 Indena SpA, Milan, Italy; 2 Polistudium Srl, Milan, Italy; 3 Complife, Pavia, Italy; 4 Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy; 5 Gematria Products, Inc., Carlsbad, CA, USA
BACKGROUND: Vitachelox® is a multi-component powder containing three botanical standardized extracts rich in polyphenols, which exerts a protective action on the skin thanks to its antioxidative, anti-inflammatory and antimicrobial properties.
METHODS: A placebo-controlled trial has been conducted to compare the changes induced by a Vitachelox®-containing product and a placebo cream in the skin resident flora of 20 acne-prone subjects. We also investigated the antioxidant properties of Vitachelox®, by assessing its antioxidant power in vitro compared with butylated hydroxytoluene (BHT), a standard antioxidant.
RESULTS: Vitachelox® reported a superior and statistically significant modulation in the hyperproliferation of Propionibacterium acnes compared with placebo, without interfering with the concentration of other commensal bacterial species such as Staphylococcus epidermidis and S. capitis. The antioxidant properties analysis showed that Vitachelox® has a considerably higher antioxidant power compared with butylated hydroxytoluene and that this effect is stable over a prolonged period of time.
CONCLUSIONS: Vitachelox® may be effective in modulating the skin microflora and reducing the P. acnes population in patients with acne-prone skin and may provide a beneficial contribution to skin health thanks to its potent antioxidant activity.
KEY WORDS: Microbiota; Acne vulgaris; Antioxidants; Polyphenols