THERAPEUTICAL NOTES   Free access

Esperienze Dermatologiche 2018 June;20(2 Suppl 1):31-4

DOI: 10.23736/S1128-9155.18.00456-9

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

A reappraisal of the anti-glycation activity of a novel Centella Asiatica extract (Centevita®)

Stefano TOGNI ¹, Giada MARAMALDI ¹ ✉, Federico FRANCESCHI ¹, Antonella RIVA ¹, Luca GIACOMELLI ², Roberto EGGENHOFFNER ², Elian LATI ³

¹ Indena SpA, Milan, Italy; ² Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy; ³ Laboratoire BIO-EC, Longjumeau, France

The term glycation describes one of the most important aging factors for human tissues and organs. It refers to the non-enzymatic process of proteins, lipids, and nucleic acids covalently bonding to the sugar molecules glucose and fructose. In recent years, the role of advanced glycation end (AGEs) products has been increasingly discussed in skin aging. The process of glycation is amplified by UV exposure and smoking that accelerate the formation of AGEs, increasing their deposition in various tissues including skin. The aim of this paper was to further assess the antiglycation properties of the purified extract of Centella Asiatica leaves (Centevita®) obtained with food-grade solvents and with a peculiar content of biologically active molecules. Furthermore, a brief description of the role of AGEs in pathogenesis of skin aging will be provided.

KEY WORDS: Centella asiatica extract - Triterpenes - Glycation end products, advanced - Skin aging - Collagen