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Esperienze Dermatologiche 2018 June;20(2):27-31

DOI: 10.23736/S1128-9155.18.00474-0

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Evaluation of the soothing effect of Eupilen® topical formulation on radiotherapy-induced dermatitis

Giada MARAMALDI 1, Ambra CORTI 2, Martino MENEGHIN 1, Maria Rosaria CESARONE 3, Roberto EGGENHOFFNER 4, Luca GIACOMELLI 2, 4 , Gianni BELCARO 3, Stefano TOGNI 1

1 Indena S.p.A, Milan, Italy; 2 Polistudium SRL, Milan, Italy; 3 Department of Medical and Oral Sciences and Biotechnology, Irvine3 Labs, University of Chieti-Pescara, Chieti, Italy; 4 Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy


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BACKGROUND: Eupilen® is a topical formulation containing a blend of natural active ingredients specifically combined to counteract sensitive skin discomfort. In this pilot study, we assessed the efficacy and safety of Eupilen® topical formulation as soothing and lenitive agent in patients undergoing radiotherapy for cancer treatment.
METHODS: We enrolled patients treated with radiation therapy for different types of cancer. All study participants freely decided to follow either a standard management (SM) protocol, consisting in the application of dexpanthenol, or SM associated with Eupilen® topical formulation (N.=19 for each group).
RESULTS: Patients treated with Eupilen® reported a consistent beneficial effect in the reduction of several radiation-induced skin damages. After 4 weeks, patients treated with Eupilen® + SM reported a marked decrease in occurrence of skin redness, skin peeling, edema and local pain associated with radiation therapy, with superior results compared to patients treated with SM alone.
CONCLUSIONS: This pilot investigation suggests that Eupilen® topical formulation may help reduce skin redness, skin peeling and others symptoms of radiation-induced skin toxicity in patients treated for cancer.


KEY WORDS: Radiodermatitis - Administration, topical - Skin diseases

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