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Esperienze Dermatologiche 2018 March;20(1):5-14

DOI: 10.23736/S1128-9155.18.00470-3


language: English

Hybrid cooperative complexes of high and low molecular weight hyaluronans (Profhilo®): review of the literature and presentation of the VisionHA project

Enis AGOLLI 1, Bianca DIFFIDENTI 2, Novella DI ZITTI 3, Enrico MASSIDDA 4, Francesco PATELLA 5, Chiara SANTERINI 6, Annalisa BEATINI 7, Michele BIANCHINI 8, Stefania BIZZARRI 9, Valentina CAMILLERI 10, Antonella GALLODORO 11, Nicoletta GRANATA 12, Sebastian LASPINA 13, Alberto LIBERTI 14, Giovanni LIZIO 15, Anna MALGIOGLIO 16, Aliona MURATOV 17, Doariano OTTAVIAN 18, Maurizio OTTI 19, Carlo PERAMEZZA 20, Mario PARISE 21, Marco UGOLINI 22, Cristina VARESI 23, Maria C. TOFFANIN 24, Gilberto BELLIA 25

1 Nuova Ricerca Day Hospital, Rimini, Italy; 2 Private Practictioner, Naples, Italy; 3 CTO Ospedale Militare, Rome, Italy; 4 Private Practictioner, Cagliari, Milan, Italy; 5 Private Practictioner, Trani, Barletta-Andria-Trani, Italy; 6 Private Practictioner, Ospedaletto, Pisa, Italy; 7 Centro Medico Laserpoint, Sarzana, La Spezia, Italy; 8 Istituto Medico Medlight Srl, Florence, Italy; 9 Istituto Neurotraumatologico Italiano, Grottaferrata, Rome, Italy; 10 Private Practictioner, Turin, Italy; 11 Private Practictioner, Taormina, Messina, Italy; 12 Santissima Trinità Hospital, Cagliari, Italy; 13 Private Practictioner, Udine, Italy; 14 Private Practictioner, Pagani, Salerno, Italy; 15 Private Practictioner, Modena, Italy; 16 Private Practictioner, Rome, Italy; 17 Private Practictioner, Desenzano del Garda, Brescia, Italy; 18 San Camillo Hospital, Treviso, Italy; 19 La Sapienza University, Rome, Italy; 20 Private Practictioner, Rimini, Italy; 21 ULSS Pedemontana, Santorso, Vicenza, Italy; 22 EasyMed Srl, Gallarate, Varese, Italy; 23 Private Practictioner, Milan, Italy; 24 Azienda Ospedaliera di Padova, Padua, Italy; 25 IBSA Farmaceutici Italia Srl, Lodi, Italy


During life, skin undergoes chrono-aging, a process characterized by the slowing of metabolic processes and normal cellular activities. Laxity, dermal thinning and wrinkles formation, major aspects of skin aging, are strictly related with a marked reduction in hyaluronic acid (HA) content in the extracellular matrix. HA has therefore become a well-known dermal agent, shown to promote collagen synthesis, stimulate fibroblast proliferation, and correct skin defects. Most HA-based products used in aesthetic medicine are based on chemical cross-linking that, while improving stability, rigidity, and elasticity, substantially modifies the natural structure of HA. Profhilo® is a novel HA preparation, based on stabilized, cooperative, hybrid complexes, produced with NAHYCO® Hybrid Technology, an innovative patented thermal production process to stabilize the HA without the use of cross-linking agents. Profhilo® has high HA concentration, low viscosity, optimal tissue diffusion, and high manageability, favoring a multilevel dynamic tissue remodeling. The effectiveness of Profhilo® in improving the extracellular environment was demonstrated in in vitro studies, and its use in aesthetic medicine by a specifically developed 5-injection points technique, has been object of publications, showing positive results in terms of skin vitality and turgidity with a good tolerability profile. In order to explore new, advanced procedures for HA use in aesthetic medicine, the VisionHA project was launched, including educational activities and experience-sharing workshops. During the VisionHA project, different combination protocols and injection techniques have been tested for different facial and body areas. A few exemplary clinical experiences are here described.

KEY WORDS: Hyaluronic acid - Skin aging - Treatment

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