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Esperienze Dermatologiche 2017 June-December;19(2-4):60-5

DOI: 10.23736/S1128-9155.17.00453-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Cutaneous expression of antiapoptotic protein c-FLIP in psoriasis

Elsayed S. HEWEDY 1, Ghada F. HASSAN 1 , Fersan A. SALLAM 2

1 Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt; 2 Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt


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BACKGROUND: Psoriasis is a chronic, relapsing, inflammatory, and hyper- proliferative skin disease. The most characteristic change in psoriasis is markedly increased and persistent keratinocyte proliferation. Defective apoptotic mechanism may be important in the pathogenesis and progression of psoriasis. c-FLIP protein is an important anti-apoptotic marker and chemotherapeutic resistant factor, which may have a role in the pathogenesis of psoriasis. The aim was to determine the c-FLIP expression in psoriasis and its role in pathogenesis of the disease.
METHODS: Forty patients of psoriasis vulgaris were enrolled in this study. Skin biopsies were obtained from psoriatic patients and twenty normal individuals served as a control group. The biopsies were examined by both H&E and immunohistochemically for c-Flip expression.
RESULTS: c-FLIP protein was expressed in the epidermis of all psoriatic lesions varying from mild to severe expression. Normal controls showed either negative expression of c-FLIP protein or faint mild expression with statistically significant increase in the psoriatic skin when compared to control. There was positive significant correlation between severity of psoriasis (detected by PASI score) and c-FLIP protein expression. There were no significant relations between c-FLIP expression and other parameters as age, sex, family history, age of onset and duration.
CONCLUSIONS: Psoriatic epidermis has increased resistance against apoptosis which may be due to increased c-FLIP expression in lesional keratinocytes. c-FLIP might be a potential new target for preventing keratinocyte proliferation in psoriasis in the future.


KEY WORDS: Psoriasis - Etiology - Proteins

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