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Esperienze Dermatologiche 2016 September-December;18(3-4):187-91

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Effective oral treatment for scalp disorders: results from a double blind, placebo-controlled study

Stefano TOGNI 1, Giada MARAMALDI 1, Martino MENEGHIN 1, Luca GIACOMELLI 2, Roberto EGGENHOFFNER 2

1 Indena S.p.A., Milan, Italy; 2 Department of Surgical Sciences and Integrated Diagnostics, School of Medicine, Genova University, Genoa, Italy


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BACKGROUND: In order to prevent and treat scalp disorders, a multi-component oral formulation containing active naturally-derived agents such as Serenoa repens (saw palmetto) extract and Vitis vinifera (grape) extract has been tested in patients with dandruff.
METHODS: This randomized, double blind, placebo-controlled study was conducted in subjects of either gender suffering from dandruff. Each subject was daily administrated one capsule of the multi-component formulation or placebo, for eight weeks. Clinical and instrumental examinations were carried out at the following time points: at inclusion, at the end of the treatment (after 8 weeks) and after 12 weeks (follow-up). The instrumental examinations included: MacGinley’s cell count (assessment of desquamated cells), sebometry and trichogram.
RESULTS: In total, 25 patients received the multi-component capsules and 25 patients received placebo. After 8 weeks of treatment with the multi-component product, the number of desquamated cells and the scalp sebum significantly decreased compared with the placebo group. Noteworthy, these beneficial effects persisted after 4 weeks of follow-up. Last, the modifications of the trichogram values in the multi-component product-treated group indicated a clinical improvement of the hair follicles.
CONCLUSIONS: Although the small sample size should be taken into account, the present study indicates that this novel multi-component oral formulation could represent an effective treatment in patients suffering from hair dandruff.

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