ORIGINAL ARTICLES   Free access

Esperienze Dermatologiche 2014 December;16(4):183-7

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

In vivo anti-inflammatory effects of vitamin K1

Fabbrocini G. ¹, Micali G. ², Bettoli V. ³, Barbareschi M. ⁴, Veraldi S. ⁴, Tedeschi A. ², Dall’Oglio F. ², Capasso C. ¹, Panariello L. ¹, Di Lorenzo P. ⁵, Varricchio S. ⁶, Montagnaro F. ⁷, Mascolo M. ⁶, Vitiello R. ⁷, Ilardi G. ⁶, Monfrecola G. ¹

¹ Section of Dermatology, Department of Clinical Medicine and Surgery, University of Federico II of Naples, Naples, Italy; ² Department of Dermatology, A.O.U. Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy; ³ Department of Clinical and Specialist Medicine, University of Ferrara, Ferrara, Italy; ⁴ Institutes of Dermatological Sciences, University of Milano, Milano, Italy; ⁵ Department of Advanced Biomedical Sciences, Chair of Forensic Medicine, University of Naples Federico II, Naples, Italy; ⁶ Pathology Section, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; ⁷ Department of Chemical Sciences, University of Naples Federico II, Naples, Italy

Acne vulgaris is a chronic disease with a multifactorial pathogenesis. It is a primary inflammatory disease: several histological, immunological, and clinical data suggest that inflammation occurs at all stages of lesion development. Vitamin K has a fundamental function in hemostasis, but it also has additional properties: it plays an important role in osteoporosis and cancer, but the mechanisms are not fully understood yet. Another function of vitamin K is the suppression of inflammation. On the basis of the anti-inflammatory and antioxidant properties of vitamin K1, we studied its possible role in patients affected by acne.