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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2014 December;16(4):183-7


language: English

In vivo anti-inflammatory effects of vitamin K1

Fabbrocini G. 1, Micali G. 2, Bettoli V. 3, Barbareschi M. 4, Veraldi S. 4, Tedeschi A. 2, Dall’Oglio F. 2, Capasso C. 1, Panariello L. 1, Di Lorenzo P. 5, Varricchio S. 6, Montagnaro F. 7, Mascolo M. 6, Vitiello R. 7, Ilardi G. 6, Monfrecola G. 1

1 Section of Dermatology, Department of Clinical Medicine and Surgery, University of Federico II of Naples, Naples, Italy; 2 Department of Dermatology, A.O.U. Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy; 3 Department of Clinical and Specialist Medicine, University of Ferrara, Ferrara, Italy; 4 Institutes of Dermatological Sciences, University of Milano, Milano, Italy; 5 Department of Advanced Biomedical Sciences, Chair of Forensic Medicine, University of Naples Federico II, Naples, Italy; 6 Pathology Section, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; 7 Department of Chemical Sciences, University of Naples Federico II, Naples, Italy


Acne vulgaris is a chronic disease with a multifactorial pathogenesis. It is a primary inflammatory disease: several histological, immunological, and clinical data suggest that inflammation occurs at all stages of lesion development. Vitamin K has a fundamental function in hemostasis, but it also has additional properties: it plays an important role in osteoporosis and cancer, but the mechanisms are not fully understood yet. Another function of vitamin K is the suppression of inflammation. On the basis of the anti-inflammatory and antioxidant properties of vitamin K1, we studied its possible role in patients affected by acne.

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