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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2013 March;15(1):3-7


language: Italian

Epidermolytic hyperkeratosis

Passarini B., Therianou A., Varotti E., Sgubbi P., Infusino S. D.

Sezione di Dermatologia, Dipartimento di Medicina Interna, dell’ Invecchiamento e Malattie Nefrologiche, Alma Mater Studiorum Università di Bologna, Bologna


Epidermolytic hyperkeratosis is a histopathological feature of some dermatoses, which can sometimes be found, occasionally or accidentally, in other skin diseases. The two clinical entities in which is peculiar the histopathological response of epidermolytic hyperkeratosis are bullous congenital ichthyosiform erythroderma and epidermolytic acantoma. The first is an autosomal dominant genodermatosis that manifests at birth with generalized erythema, followed after a few days by the onset of brown and thick scales and sometimes by blisters and bubbles. The epidermolytic acantoma is a clinical entity that can occur in solitary form, with the onset of a warty or papillomatous papule, ubiquitous, or disseminated form with lesions seborrheic keratosis-like, prevailing at the back and genital area. A histopathological picture of epidermolytic hyperkeratosis can be found in some forms of hereditary palmoplantar keratoderma, for example in the form of Vörner, in the epidermal nevus and in nevus comedonicus. The epidermolytic hyperkeratosis, finally, can be found accidentally in other clinical conditions such as seborrheic keratoses, trichilemmal cysts, sebaceous hyperplasia, intradermal melanocytic nevus, actinic keratosis, superficial basal cell carcinoma, squamous cell carcinoma, annulare granuloma, hypertrophic scar.

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