Home > Journals > Esperienze Dermatologiche > Past Issues > Esperienze Dermatologiche 2012 September;14(3) > Esperienze Dermatologiche 2012 September;14(3):97-103

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

SPECIAL ARTICLES   

Esperienze Dermatologiche 2012 September;14(3):97-103

Copyright © 2012 EDIZIONI MINERVA MEDICA

language: Italian

Filaggrin (and other scleroproteins) in immune-mediated skin diseases

Di Stanislao C., Flati G., Biamonte A. S.

UOC di Dermatologia – UOS Di Allergologia, ASL - 01 Avezzano, Sulmona, L’Aquila; PO S. Salvatore, Dipartimento di Medicina, L’Aquila


PDF


Filaggrin is an essential scleroprotein in the formation of basophil keratohyalin granules, the development of the corneal lamellae and natural moisturizing factor responsible for skin hydration. Recent studies have associated filaggrin with several genetic loci and its role in causing immune-mediated skin disorders such as atopic dermatitis, photoallergies, and contact dermatitis. This article summarizes salient data on pathogenetic processes in which reduced filaggrin production is correlated with various skin conditions.

top of page