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Esperienze Dermatologiche 2008 June;10(2):63-7

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English, Italian

Acanthosis nigricans associated with poorly differentiated gastric adenocarcinoma

Calista D. 1, Reggiani M. 2

1 Unità Operativa di Dermatologia, Ospedale M Bufalini, Cesena 2 Unità Operativa di Dermatologia, Ospedale Bellaria, Bologna


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Malignant acanthosis nigricans is an extremely rare obligate paraneoplastic dermatosis chiefly associated with gastrointestinal neoplasia. This case report describes a 64-year-old man with acanthosis nigricans associated with silent advanced-stage gastric adenocarcinoma. The skin manifestations appeared 8 weeks before the patient presented to the unit; diagnostic studies revealed the site of the tumor. A gastrectomy was performed in conjunction with palliative chemotherapy because of metastasis to the lymph nodes of the small gastric curve. Regression of the skin manifestations allowed the patient to resume a normal social life. The patient died 8 months after initial presentation because of metastatic spread of disease.

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