CASE REPORT  NON-COVID-19 SECTION Open access

Italian Journal of Emergency Medicine 2021 December;10(3):168-71

DOI: 10.23736/S2532-1285.21.00103-8

Copyright © 2021 THE AUTHORS

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language: English

Lethal allopurinol induced Lyell Syndrome

Cristina SAGRAFOLI ¹ ✉, Alessio AGOSTINI ², Luigina De BENEDETTO ², Massimo MAGNANTI ¹

¹ Unit of First Aid and Emergency Medicine, Emergency Department, San Filippo Neri Hospital, ASL Roma 1, Rome, Italy; ² Unit of First Aid, Emergency Department, San Filippo Neri Hospital, ASL Roma 1, Rome, Italy

Toxic epidermal necrolysis represents a rare acute and very serious dermatological disease, associated with high mortality and morbidity. It is characterized by the destruction of skin and mucous membranes, mostly due to a “drug allergy” with a genetic predisposition HLA-B12 and HLA-B1502. We reported the case of a 65-year-old woman admitted in Emergency Department with skin erythema spread over the whole body. She presented a shock condition with multiple organ failure which required a multidisciplinary approach with ulcer dressing and supportive care in intensive care unit. Specific immunoglobulin therapy by vein has been unsuccessfully attempted.

KEY WORDS: Necrosis; Epidermal cells; Immunization, passive; Skin