Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Articles online first > Giornale Italiano di Dermatologia e Venereologia 2020 Oct 16

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as

 

 

Giornale Italiano di Dermatologia e Venereologia 2020 Oct 16

DOI: 10.23736/S0392-0488.20.06622-5

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Prognostic significance of Bcl-2 expression in primary cutaneous B-cell lymphoma: a reappraisal

Alessandro PILERI 1 , Claudio AGOSTINELLI 2, Clara BERTUZZI 2, Vieri GRANDI 3, 4, Vincenza MAIO 5, Irene LASTRUCCI 3, Marco SANTUCCI 5, Nicola PIMPINELLI 3

1 Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; 2 Department of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada; 3 Dermatology Unit, Department of Health Sciences, University of Florence Medical School, Florence, Italy; 4 St John's Institute of Dermatology, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, UK; 5 Pathological Anatomy Unit, Department of Health Sciences, University of Florence Medical School, Florence, Italy


PDF


INTRODUCTION: Bcl-2 family protein plays an important role in apoptosis and its overexpression is protects neoplastic cell from apoptotic stimuli. Cutaneous B-cell lymphoma are rare non-Hodgkin lymphomas and can be classified in primary forms, featuring an exclusive skin-involvement at diagnosis, and cutaneous spread of a nodal disease. Such a distinction is not trivial, owing to different prognosis (indolent vs. aggressive) and therapeutic management.
EVIDENCE ACQUISITION: Bcl-2 expression at immunohistochemistry can be crucial in differential diagnosis between cutaneous and systemic disease, as well as between the different primary cutaneous forms.
EVIDENCE SYNTHESIS: In the last few years, an animated debate on the prognostic role of BCL-2 overexpression at molecular analysis have been developed in cutaneous B-cell lymphoma.
CONCLUSIONS: Bcl-2 expression have a diagnostic role more than prognostic in primary cutaneous B-cell lymphomas.


KEY WORDS: Cutaneous B-cell lymphoma; Follicle center B-cell lymphoma; Marginal zone B-cell lymphoma; Diffuse large B-cell lymphoma; Bcl-2

top of page