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Giornale Italiano di Dermatologia e Venereologia 2020 Oct 07

DOI: 10.23736/S0392-0488.20.06598-0

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

5-Aminolaevulinic acid patch photodynamic therapy for the treatment of actinic keratoses: preliminary results from an Italian study in the real-life setting

Annunziata DATTOLA 1, Carlota GUTIÉRREZ GARCÍA-RODRIGO 2, Sara TAMBONE 3, 4, Virginia GAROFALO 1, Astrid LAPPI 1, Erika V. DE LUCA 3, 4, Ketty PERIS 3, 4, Luca BIANCHI 1, Elena CAMPIONE 1, Maria Concetta FARGNOLI 2

1 Department of Dermatology, University of Rome “Tor Vergata”, Rome, Italy; 2 Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; 3 Institute of Dermatology, Catholic University of the Sacred Heart, Rome, Italy; 4 Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy


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BACKGROUND: Photodynamic therapy (PDT) is recommended for both lesion and field therapy of actinic keratoses (AKs). The 5-aminolaevulinic acid (5-ALA) patch PDT is indicated for the treatment of isolated mild AKs (≤1.8 cm) on the face and bald scalp and was demonstrated to be effective and safe in clinical trials with a good tolerability profile.
METHODS: In this retrospective multicenter real-life study, 33 patients with a total of 99 AKs of the scalp, face, ears, and/or hands and 2 actinic cheilitis were treated with one treatment session of 5-ALA patch PDT with a red light source (total dose of 37 J/cm²).
RESULTS: Overall, 12 weeks after treatment, 68/99 (69%) lesions were completely cleared. Complete response was obtained in 82% of AKs on the ears, 78% on the face, 57% on the hands, and 56% on the scalp and in the two actinic cheilitis. The treatment was very effective on grade I AKs, cleared in 87% of the cases and less efficient on grade II-III lesions, cleared in 47% of the cases. 5-ALA patch PDT was well tolerated with a good to excellent cosmetic outcome in 97% of the patients and with 94% of the patients being satisfied or very satisfied with the treatment.
CONCLUSIONS: Our results confirm that 5-ALA patch PDT is a good option for AK treatment in clinical practice, it is easy to use, effective and well tolerated even in difficult-to-treat-areas and has an excellent cosmetic outcome.


KEY WORDS: Actinic keratosis; Photodynamic therapy; 5-aminolaevulinic acid patch

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