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Giornale Italiano di Dermatologia e Venereologia 2020 Apr 29

DOI: 10.23736/S0392-0488.20.06551-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

What makes an inflammatory disease inflammatory? An overview of inflammatory mechanisms of allergic contact dermatitis, atopic dermatitis and psoriasis

Eleonora FARINAZZO 1, Roberta GIUFFRIDA 2 , Caterina DIANZANI 3, Roberta VEZZONI 1, Chiara RETROSI 1, Nicola DI MEO 1, Iris ZALAUDEK 1, Claudio CONFORTI 1

1 Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy; 2 Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, Italy; 3 Dermatology Section, Department of Plastic, Reconstructive and Cosmetic Surgery, Campus Biomedico University Hospital, Rome, Italy


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Inflammatory response in the skin is important for host defence against a broad spectrum of insults including microorganisms, chemicals, radiation and physical trauma. When the inflammatory process becomes prolonged and self-perpetuating, illness occurs. In this review, we discuss recent findings regarding the complex inflammatory mechanisms in allergic contact dermatitis, atopic dermatitis and psoriasis.


KEY WORDS: Psoriasis; Atopic dermatitis; Allergic contact dermatitis; Inflammation; Skin disorders

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