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Giornale Italiano di Dermatologia e Venereologia 2018 Nov 09

DOI: 10.23736/S0392-0488.18.06094-7

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Ixekizumab for treatment of moderate to severe plaque psoriasis: real world clinical experience

Federico DIOTALLEVI, Anna CAMPANATI, Giulia RADI , Elisa MOLINELLI, Annamaria OFFIDANI

Department of Clinical and Molecular Sciences, Dermatological Clinic, Polytechnic Marche University, Ancona, Italy


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BACKGROUND: Data concerning clinical experience in real world setting with ixekizumab for psoriasis are still exiguous and aim of this report is to provide our experience in the use of ixekizumab in out-patient setting.
METHODS: Fifteen Caucasian individuals (10 male, 5 females; mean age 58.1; range 30-75 years) affected by moderate to severe plaque psoriasis (PASI≥10 e/o DLQI≥10 e/O BSA≥10) were treated with Ixekizumab, following dosing regimen of technical data sheet and clinically evaluated both after 4 weeks (T4) and 12 weeks (T12) after. At baseline median PASI was 16.3 (range 10 -30, SD 6.0). The median BSA was 21.3 (10 - 35, SD 7.0), the median PGA was 3.4 (2 - 6, SD 1.2), the median DLQI was 18.6 (14 - 25, SD 3.6), the median m-NAPSI was 42.0 (30-56, SD 13.11). The median absolute value of PASI, BSA, PGA, DLQI and m-NAPSI showed a statistically significant decrease (p<0.05) already after 4 weeks of treatment, to testify tratment effectiveness.
RESULTS: At T4, 93.3% of the patients reached PASI 50, 6.9% reached PASI75; at T12 100% ofthe patients reached PASI50, 80% reached PASI75, 13% reached PASI 90 and 6.9% reached PASI 100. One-third of observed patients reached MDA after 12 weeks of treatment. Injection site reactions were the only side effects occurring during the first 12 weeks of treatment.
CONCLUSIONS: Our preliminary results seem to confirm the efficacy and safety profile provided through the UNCOVER pivotal trials (UNCOVER 1-3) although further larger observational studies are needed.


KEY WORDS: Psoriasis - Ixekizumab - MDA - Efficacy - Safety

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