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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2018 Feb 07

DOI: 10.23736/S0392-0488.18.05907-2

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Can daylight-PDT be performed indoor?

Serge MORDON 1 , Anne S. VIGNION-DEWALLE 1, Elise THECUA 1, Claire VICENTINI 1, 2, Cyril MAIRE 1, 2, Pascal DELEPORTE 1, Gregory BAERT 1, Fabienne LECOMTE 1, Laurent MORTIER 1, 2

1 Université de Lille, Inserm, CHU Lille, U1189, ONCO-THAI, Image Assisted Laser Therapy for Oncology, Lille, France; 2 Department of Dermatology, CHU Lille, Lille, France


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Natural DayLight-mediated PhotoDynamic Therapy (NDL-PDT) is an efficacious treatment option for thin actinic keratosis that offers advantages over conventional PDT in terms of tolerability, treatment duration, and cost. It is now accepted that the minimum criteria required for effective NDL-PDT is a dose of 4 J/cm2 with a treatment time of 2 h and a minimum temperature of 10°C, corresponding to a minimum illuminance of 11 000 lux. This value is easily achievable: 20 000 lux can be obtained during a typical overcast day at midday. It can reach 110 000 lux with a bright sunlight However, it is limited to certain times of the year at our latitude. However rain and cold temperatures appear the main limitations of NDL-PDT. Greenhouses make possible to perform the illumination even in harsh weather conditions. Furthermore, it is difficult to install a greenhouse everywhere. Several solutions are now proposed to carry out indoor illumination so-called artificial white light or simulated daylight (SDL-PDT). Illumination sources installed at the ceiling of the treatment room is one option. Several lamp pairs can be combined to illuminate groups of patients simultaneously. A surgical theatre light can be used or dedicated systems using white LEDs can be used to deliver the required illumination dose. In conclusion, Indoor lightning (or simulated daylight: SDL-PDT or Artificial White Light: AWL) could offer an interesting alternative to NDL-PDT.


KEY WORDS: Photodynamic therapy - Actinic keratosis - Light emitting diode - Artificial white light

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Publication History

Article first published online: February 7, 2018
Manuscript accepted: February 6, 2018
Manuscript received: January 8, 2018

Cite this article as

Mordon S, Vignion-Dewalle AS, Thecua E, Vicentini C, Maire C, Deleporte P, et al. Can daylight-PDT be performed indoor? G Ital Dermatol Venereol 2018 Feb 07. DOI: 10.23736/S0392-0488.18.05907-2

Corresponding author e-mail

serge.mordon @inserm.fr