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Giornale Italiano di Dermatologia e Venereologia 2018 Feb 07

DOI: 10.23736/S0392-0488.18.05765-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Efficacy of a detergent combined with a moisturiser for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi’s sarcoma

Athanasia TOURLAKI 1 , Giovanni GENOVESE 1, Dario CONSONNI 2, Lucia BRAMBILLA 1

1 Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, U.O. Dermatologia, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2 U.O. Epidemiologia, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy


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BACKGROUND: Xerosis is common among patients with Kaposi’s sarcoma (KS). The aim of our study was to evaluate the efficacy of a detergent containing dihydroavenanthramide D 5% combined with a moisturiser containing 1% of menthol for the treatment of chronic pruritus associated with xerosis in elderly KS patients.
METHODS: We conducted a prospective, open-label, intra-individual, right/left comparative study. During the 4-week treatment study, patients used the test products on the right lower limb, and a basic skin cleanser plus basic cream on their left lower limb, in a predefined protocol. A 10 cm Visual Analogue Scale (VAS), the hydration index (HI) of the stratum corneum and the Overall Dry Skin Score (ODSS) were used to assess pruritus and xerosis severity on admission, at 2 and 4 weeks.
RESULTS: Thirty patients (24 males, 6 females, mean age: 76.6 ± 6.8 years) were enrolled. At the end of 4 weeks, the mean pruritus VAS score declined from 4.2±2.2 to 1.7±1.4 on the right side, and from 4.2±2.2 to 2.3±1.5 on the left side. The HI score increased from 25.6±15.0 to 46.1±12.3 on the right side, and from 26.0±15.2 to 35.4±12.6 on the left side. Differences between the right and left limbs were significant for VAS score (p=0.0064), HI (p<0.0001) and ODSS values (p=0.0049). There was no adverse reaction to the test products.
CONCLUSIONS: Daily use of a detergent containing dihydroavenanthramide D 5% combined with a moisturiser containing 1% of menthol improves chronic pruritus associated with xerosis in elderly adults with KS.


KEY WORDS: Pruritus - Dry skin - Kaposi’s sarcoma - Moisturiser - Menthol - Dihydroavenanthramide D

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