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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2018 Feb 07

DOI: 10.23736/S0392-0488.18.05710-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Novel combination for the treatment of acne differentiated according to gender: a new step towards personalized treatment

Ersilia TOLINO , Nevena SKROZA, Alessandra MAMBRIN, Nicoletta BERNARDINI, Sara ZUBER, Veronica BALDUZZI, Anna MARCHESIELLO, Ilaria PROIETTI, Concetta POTENZA

Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Science and Biotechnologies, A. Fiorini Hospital, Sapienza University of Rome, Terracina, Latina, Italy


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BACKGROUND: The aim of this study is to evaluate efficacy and tolerability of a complete skin care line consisting of an oral supplement in two distinct formulations for males and females, and a topical cream device in the treatment of mild and moderate acne. Oral supplements contain biotin, probiotic, vitamin E, zinc, nicotinamide; in the formulation for males beta sitosterol and boswella serrata were added, the oral supplement for females contains myo-inositol and folic acid. The topical cream device is represented by the association between active plant agents (verbascoside, ocimum gratissimum) and keratolytic molecules (salicylic acid, gluconolactone, complex alpha-hydroxy acids).
METHODS: An equal number of male and female patients with mild to moderate acne were enrolled in a double-blinded clinical trial. Efficacy and tolerability evaluations were performed at week 4 (T1) and week 12 (T2) by Global acne Grading System (GAGs).
RESULTS: Most of patients had satisfactory therapeutic response, in terms of GAGs reduction.. All the four groups presented a statistically significant improvement of the mean GAGs at T2 but those assuming the oral supplement improved more, as expected.
CONCLUSIONS: Our data suggest that this association can be considered a new effective option for mild and moderate acne. This therapeutic line differs from others in the gender matched oral treatment.


KEY WORDS: Acne - Topical treatment - Oral supplement

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Publication History

Article first published online: February 7, 2018
Manuscript accepted: February 6, 2018
Manuscript revised: January 26, 2018
Manuscript received: June 7, 2017

Cite this article as

Tolino E, Skroza N, Mambrin A, Bernardini N, Zuber S, Balduzzi V, et al. Novel combination for the treatment of acne differentiated according to gender: a new step towards personalized treatment. G Ital Dermatol Venereol 2018 Feb 07. DOI: 10.23736/S0392-0488.18.05710-3

Corresponding author e-mail

ersiliatolino@gmail.com