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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 Dec 15

DOI: 10.23736/S0392-0488.17.05801-1

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Vitamin D and melanoma: state of the art and possible therapeutic uses

Giovanni PAOLINO 1, Elisa MOLITERNI 1 , Paola CORSETTI 1, Dario DIDONA 2, Ugo BOTTONI 3, Stefano CALVIERI 1, Carlo MATTOZZI 1

1 Dermatologic Clinic, Sapienza University of Rome, Rome, Italy; 2 Prima Divisione Dermatologica, Istituto Dermopatico dell’Immacolata-IRCCS, Rome, Italy; 3 Dipartimento di Dermatologia, Università Magna Grecia di Catanzaro, Catanzaro, Italy


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Despite the presence of several studies in literature, the real connection between vitamin D serological levels, vitamin D receptor and melanoma remains unclear, probably because of the complex correlation between vitamin D and melanoma. Indeed, UV radiations are not reported as the main risk factor for melanoma in non-sun-exposed, while systemic immunosuppression, anatomical and physiological features may contribute to malignancy. Therefore, the correlation between melanoma cells in sun- exposed areas and vitamin D, as well as vitamin D receptor could be different from the one in melanoma of sun-shielded sites. These differences may also explain the controversial results reported in the literature regarding the correlation between melanoma and vitamin D, as well as the different outcomes in melanoma patients treated with vitamin D as adjuvant therapy. The aim of this review is to highlight the most recent findings about vitamin D and melanoma, focusing on the anatomic site of the primary tumor as well as on the possible therapeutic uses of vitamin D in melanoma patients.


KEY WORDS: Melanoma - Vitamin D - Therapy - Cancer - Antiproliferative

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Publication History

Article first published online: December 15, 2017
Manuscript accepted: December 12, 2017
Manuscript received: October 5, 2017

Cite this article as

Paolino G, Moliterni E, Corsetti P, Didona D, Bottoni U, Calvieri S, et al. Vitamin D and melanoma: state of the art and possible therapeutic uses. G Ital Dermatol Venereol 2017 Dec 15. DOI: 10.23736/S0392-0488.17.05801-1

Corresponding author e-mail

elisa.moliterni@gmail.com