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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 Nov 30

DOI: 10.23736/S0392-0488.17.05818-7

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Mast cells and cancer: a review of literature

Giovanni PAOLINO 1, Paola CORSETTI 1, Elisa MOLITERNI 1, Serena CORSETTI 2 , Dario DIDONA 3, Marcello ALBANESI 4, Carlo MATTOZZI 1, Paolo LIDO 5, Stefano CALVIERI 1

1 Clinica Dermatologica, Sapienza Università di Roma, Roma, Italy; 2 Department of Medical Oncology, Centro di Riferimento Oncologico CRO, San Vito al Tagliamento, Italy; 3 Prima Divisione Dermatologica, Istituto Dermopatico dell'Immacolata IRCCS di Roma, Roma, Italy; 4 Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, Italy; 5 Internal Medicine Residency Program , University of Rome "Tor Vergata", Rome, Italy


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Mast cells (MCs) are a potent proangiogenic factor in tumors, they product several pro- angiogenic factors such as fibroblast growth factor 2 (FGF-2), vascular epithelial growth factor (VEGF), tryptase and chymase. Tryptase is a serine protease classified as α-tryptase and β-tryptase, both produced by MCs. Tryptase degrades the tissues, playing an important role in angiogenesis and in the development of metastases. Serum tryptase increases with age, with increased damage to cells and risk of developing a malignancy and it could be considered the expression of a fundamental role of MCs in tumor growth or, on the contrary, in the antitumor response. Many biomarkers have been developed in clinical practice for improving diagnosis and prognosis of some neoplasms. Elevated tryptase levels are found in subgroups of patients with haematologic and solid cancers. In the current review, we want to update the perspectives of tryptase as a potential biomarker in daily practice in different neoplasms.


KEY WORDS: Mast cells - Tryptase - Cancer

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Publication History

Article first published online: November 30, 2017
Manuscript accepted: November 14, 2017
Manuscript received: October 16, 2017

Cite this article as

Paolino G, Corsetti P, Moliterni E, Corsetti S, Didona D, Albanesi M et al. Mast cells and cancer: a review of literature. G Ital Dermatol Venereol 2017 Nov 30. DOI: 10.23736/S0392-0488.17.05818-7

Corresponding author e-mail

serena.corsetti@cro.it