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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 Nov 16

DOI: 10.23736/S0392-0488.17.05622-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Correlation between plasmatic levels of Vitamin D and PASI score: our experience and mini-review of the literature

Carlo MATTOZZI 1 , Giovanni PAOLINO 1, Monica SALVI 1, Laura MACALUSO 1, Marco SCARNO' 2, Gaetano DE VITA 3, Stefano CALVIERI 1, Antonio G. RICHETTA 1

1 Department of Internal Medicine and Medical Specialties, UOC of Dermatology and Venereology, University of Rome “Sapienza”, Rome, Italy; 2 CINECA (Inter University Consortium for Super Computing), Rome, Italy; 3 Department of Physics, University of Calabria and IPCF-CNR, UOS of Cosenza, Rende, Cosenza, Italy


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BACKGROUND: Psoriasis is a common, inflammatory, chronic, relapsing skin disease. The pathogenesis is multifactorial and it is involved both innate and acquired immunity. Several studies have shown the important role of vitamin D in the pathogenesis of this disorder. In this study we have evaluated a possible correlation between vitamin D and clinical severity of psoriasis calculated with PASI score.
METHODS: In this case control study we included 141 Caucasian subjects affected by moderate to severe psoriasis and 62 healthy controls. We have calculated PASI score and serum levels of Vitamin D.
RESULTS: Psoriatic patients had significantly lower serum levels of 25(OH)D than healthy controls. Using no parametric Spearman’s Coefficient test between serum levels of vitamin D and the PASI-score we found a statistical significant correlation. However, the statistical significance was not reached analyzing separately the patients with psoriatic arthritis, while it was confirmed for patients without an articular involvement.
CONCLUSIONS: Our study confirm that serum levels of vitamin D are significantly lower in psoriatic patients and correlate with the clinical severity of psoriasis; these data suggest that psoriatic patients could be screened for vitamin D insufficiency for a more comprehensive management.


KEY WORDS: Psoriasis - Vitamin D - Cutaneous inflammation - PASI score

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Publication History

Article first published online: November 16, 2017
Manuscript accepted: November 14, 2017
Manuscript revised: October 30, 2017
Manuscript received: February 28, 2017

Cite this article as

Mattozzi C, Paolino G, Salvi M, Macaluso L, De Vita G et al. Correlation between plasmatic levels of Vitamin D and PASI score: our experience and mini-review of the literature. G Ital Dermatol Venereol 2017 Nov 16. DOI: 10.23736/S0392-0488.17.05622-X

Corresponding author e-mail

carlo.mattozzi@gmail.com