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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 Oct 23

DOI: 10.23736/S0392-0488.17.05774-1

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The association between serum vitamin D levels and urticaria: a meta-analysis of observational studies

Xiaoyan WANG 1, Xiaorong LI 1, Yiwei SHEN 2, Xueyan WANG 1

1 Allergy Department, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; 2 Research Diversion, Beijing Shijitan Hospital, Capital Medical University, Beijing, China


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BACKGROUND: Despite the recent studies revealed Vitamin D may play a role in urticaria, no meta-analysis providing definite conclusions in this field has been reported.
METHODS: A systematic search up to 30thJune 2017 was conducted in MEDLINE (via PubMed) and Excerpta Medica database (EMBASE) to identify relevant articles. Search terms included ‘‘vitamin D’’ or “25-hydroxyvitamin D” or ‘‘25hydroxy-vitaminD” or “25(OH)D” or “1,25-dihydroxyvitamin D” combined with ‘‘urticaria”.
RESULTS: Initial searches yielded 30 citations. Of these original results, 10 met specific selection criteria and were included in the meta-analysis with 547 urticaria cases and 517 controls.The vitamin D levels was significantly decreased in the urticarial cases (WMD -9.8 mg/L, 95% CI: -12.57 to -7.04 mg/L, from a random effects model), with a significant heterogeneity (I2 =85.9%, P=0.000). When divide the Vitamin D level into two subgroups, the pooled OR comparing Vitamin D insufficiency vs normal level was 1.64 (95%CI:0.71-3.77). Meanwhile, Vitamin D deficiency vs normal level was4.09 (95%CI: 1.32-12.73).
CONCLUSIONS: The study demonstrated that patients with urticaria had a lower Vitamin D level than healthy controls. Vitamin D deficiency rather than insufficiency has a positive relationship with urticaria. However, larger-scale studies over alonger duration of treatment are needed to confirm this conclusion.


KEY WORDS: Vitamin D - 25-hydroxyvitamin D - Chronic urticaria - Meta analysis - Observational study

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Publication History

Article first published online: October 23, 2017
Manuscript accepted: September 14, 2017
Manuscript received: August 31, 2017

Cite this article as

Wang X, Li X, Shen Y, Wang X. The association between serum vitamin D levels and urticaria: a meta-analysis of observational studies. G Ital Dermatol Venereol 2017 Oct 23. DOI: 10.23736/S0392-0488.17.05774-1

Corresponding author e-mail

allergy_wxy@126.com