Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2020 August;155(4) > Giornale Italiano di Dermatologia e Venereologia 2020 August;155(4):477-82

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as

 

ORIGINAL ARTICLE   

Giornale Italiano di Dermatologia e Venereologia 2020 August;155(4):477-82

DOI: 10.23736/S0392-0488.18.05897-2

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Is HERV-K and HERV-W expression regulated by mir-155 in Sézary Syndrome?

Massimiliano BERGALLO 1 , Valentina DAPRÀ 1, Mauro NOVELLI 2, Marco RASSU 1, Paola MONTANARI 1, Ilaria GALLIANO 1, Pietro QUAGLINO 2, Maria T. FIERRO 2

1 Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Turin, Italy; 2 Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy



BACKGROUND: According to the latest update, 2578 unique mature miRNAs are currently annotated in the human genome and participate in the regulation of multiple events, such as cellular proliferation or apoptosis. A previous study analyzing global miRNA expression patterns in GH cells (high HERV-K versus low) showed that two miRNAs (miR-663 and miR-638) are differentially regulated and exhibit expression parallel to that of HERV-K. The aim of this study was to evaluate HERV-K and -W pol gene and mir-155 expression in SS patients and possible relationship between them.
METHODS: The comparison between SS patients and healthy donor showed a significant difference in terms of mir-155 expression P=0.0003 as previously reported by our groups.
RESULTS: We demonstrated that HERV-K and -W pol gene expression was significantly higher in SS patients vs. healthy donor as previously reported by our groups. Our correlation data suggest that miR-155 are not directly involved in regulating the HERVs.
CONCLUSIONS: Furthermore, further studies including other cohorts of pathology with mir-155 and HERVs involvement such as inflammatory diseases are needed to investigate the role of mir-155 in the cross-activations of HERVs.


KEY WORDS: Sezary syndrome; Gene expression; Inflammation

top of page