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Giornale Italiano di Dermatologia e Venereologia 2019 August;154(4):466-79

DOI: 10.23736/S0392-0488.17.05670-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Primary cutaneous B-cell lymphoma: narrative review of the literature

Vieri GRANDI 1 , Silvia ALBERTI VIOLETTI 2, Roberta LA SELVA 3, Stefano CICCHELLI 3, Chiara DELFINO 1, Paolo FAVA 3, Maria T. FIERRO 3, Alessandro PILERI 1, 4, Nicola PIMPINELLI 1, Pietro QUAGLINO 3, Emilio BERTI 2

1 Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence Medical School, Florence, Italy; 2 Unit of Dermatology, IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy; 3 Clinic of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy; 4 Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy



Primary cutaneous B-cell lymphomas comprehend a group of lymphoproliferative disorders characterized by being monoclonal proliferations of B-cell primarily involving the skin. Despite being recognized as autonomous and distinct clinico-pathologic entities since the late 80s, their classification is still an ongoing matter of debate. At the moment, WHO classification recognizes three disorders: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large b-cell lymphoma (leg type). Primary cutaneous diffuse large b-cell lymphoma (other) has been used to define rare cases which show histologically an infiltrate with diffuse pattern composed by large b-cell, but not fitting with criteria for follicle center lymphoma nor for primary cutaneous diffuse large b-cell lymphoma (leg type). Aim of this review was to briefly describe all recognized and provisional entities included in the primary cutaneous b-cell lymphomas and to discuss recent acquisitions that may influence their future classifications.


KEY WORDS: Lymphoma B-cell; Lymphoma, large B-cell, diffuse; Lymphoma, non Hodgkin

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