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Giornale Italiano di Dermatologia e Venereologia 2018 August;153(4):459-63

DOI: 10.23736/S0392-0488.16.05399-2

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Oral lichen planus: therapy and phenotype

Bruno LORÉ 1, Rosita SARACENO 2 , Giulio POLADAS 1, Monika FIDA 3, Charbel KHOURY 1, Claudio ARCURI 4, Roberto MAGNATO 1

1 Department of Otolorology and Maxillofacial Surgery, F. Tappeiner Hospital, Merano, Bolzano, Italy; 2 Unit of Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3 Department of Dermatology, Medical University of Tirana, Tirana, Albania; 4 Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy


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BACKGROUND: Lichen planus (LP) is a mucocutaneous disease of chronic inflammatory nature. Although many therapeutic options are available, none are curative. The aim of this article was to describe a therapeutic algorithm that take into consideration the clinical futures of oral LP (OLP).
METHODS: Patients affected by symptomatic OLP were enrolled into three groups to receive cyclosporine mouthwash, retinoic acid lotion 0.05%, and autologous platelet-rich plasma (PRP) gel in the treatment of reticular, plaque-like, and erosive-type respectively. The products were applied as follows: retinoic acid BID for 8 weeks, cyclosporine mouthwash OD for 8 weeks, PRP once a week for 8 weeks. Patients were assessed at 2, 4, 8, and 12 weeks. Improvement was evaluated as complete response, partial response and no response.
RESULTS: A total of 20 Caucasian patients, 8 male and 12 female, mean age 56 years (range 40-74) concluded the study. Seven patients showed a complete response, 7 patients a partial response, and 6 patients no response.
CONCLUSIONS: We propose a therapeutic algorithm that take into consideration the clinical features and symptoms of OLP. Long-term experience on larger series of cases are necessary to confirm our data.


KEY WORDS: Lichen planus, oral - Cyclosporine - Platelet-rich plasma

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